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Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
Joint Authors
Albeiroti, Sami
Soroosh, Artin
de la Motte, Carol A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fibrosis is a debilitating condition that can lead to impairment of the affected organ’s function.
Excessive deposition of extracellular matrix (ECM) molecules is characteristic of most fibrotic tissues.
Fibroblasts activated by cytokines or growth factors differentiate into myofibroblasts that drive fibrosis by depositing ECM molecules, such as collagen, fibronectin, and connective tissue growth factor.
Transforming growth factor-β (TGF-β) is one of the major profibrotic cytokines which promotes fibrosis by signaling abnormal ECM regulation.
Hyaluronan (HA) is a major ECM glycosaminoglycan that is regulated by TGF-β and whose role in fibrosis is emerging.
Aside from its role as a hydrating, space filling polymer, HA regulates different cellular functions and is known to have a role in wound healing and inflammation.
Importantly, HA deposition is increased in multiple fibrotic diseases.
In this review we highlight studies that link HA to fibrosis and discuss what is known about the role of HA, its receptors, and its anabolic and catabolic enzymes in different fibrotic diseases.
American Psychological Association (APA)
Albeiroti, Sami& Soroosh, Artin& de la Motte, Carol A.. 2015. Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056732
Modern Language Association (MLA)
Albeiroti, Sami…[et al.]. Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056732
American Medical Association (AMA)
Albeiroti, Sami& Soroosh, Artin& de la Motte, Carol A.. Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056732