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Abnormal Expression of Prostaglandins E2 and F2α Receptors and Transporters in Patients with Endometriosis
Joint Authors
Pouliot, Marc
Akoum, A.
Rakhila, Halima
Bourcier, Nathalie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To investigate the level of expression of prostaglandin receptivity and uptake factors in eutopic and ectopic endometrium of women with endometriosis.
Design.
Prospective study.
Setting.
Human reproduction research laboratory.
Patients.
Seventy-eight patients with endometriosis and thirty healthy control subjects.
Intervention(s).
Endometrial and endometriotic tissue samples were obtained during laparoscopic surgery.
Main Outcome Measure(s).
Real-time polymerase chain reaction assay of mRNA encoding prostaglandin E2 receptors (EP1, EP2, EP3, and EP4), prostaglandin F2α receptor (FP), prostaglandin transporter (PGT), and multidrug resistance-associated protein 4 (MRP4); immunohistochemical localization of expressed proteins.
Results.
Marked increases in receptors EP3, EP4, and FP and transporters PGT and MRP4 in ectopic endometrial tissue were noted, without noticeable change associated with disease stage.
An increase in EP3 expression and decreases in FP and PGT were observed in the eutopic endometrium of endometriosis patients in conjunction with the phases of the menstrual cycle.
Conclusion(s).
This study is the first to demonstrate a possible relationship between endometriosis and enhanced prostaglandin activity.
In view of the wide range of prostaglandin functions, increasing cell receptivity and facilitating uptake in endometrial tissue could contribute to the initial steps of overgrowth and have an important role to play in the pathogenesis and symptoms of this disease.
American Psychological Association (APA)
Rakhila, Halima& Bourcier, Nathalie& Akoum, A.& Pouliot, Marc. 2015. Abnormal Expression of Prostaglandins E2 and F2α Receptors and Transporters in Patients with Endometriosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056802
Modern Language Association (MLA)
Rakhila, Halima…[et al.]. Abnormal Expression of Prostaglandins E2 and F2α Receptors and Transporters in Patients with Endometriosis. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056802
American Medical Association (AMA)
Rakhila, Halima& Bourcier, Nathalie& Akoum, A.& Pouliot, Marc. Abnormal Expression of Prostaglandins E2 and F2α Receptors and Transporters in Patients with Endometriosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056802