The Applicability of the International Staging System in Chinese Patients with Multiple Myeloma Receiving Bortezomib or Thalidomide-Based Regimens as Induction Therapy: A Multicenter Analysis
Joint Authors
Du, Juan
Lu, Jing
Lu, Jin
Liu, Aijun
Fu, Weijun
Huang, Xiaojun
Chen, Wenming
Hou, Jian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The International Staging System (ISS) is the most important prognostic system for multiple myeloma (MM).
It was identified in the era of conventional agents.
The outcome of MM has significantly changed by novel agents.
Thus the applicability of ISS system in the era of novel agents in Chinese patients needs to be demonstrated.
We retrospectively analyzed the clinical outcomes and prognostic significance of ISS system in 1016 patients with newly diagnosed multiple myeloma in Chinese patients between 2008 and 2012, who received bortezomib- or thalidomide-based regimens as first-line therapy.
The median overall survival (OS) of patients for ISS stages I/II/III was not reached/55.4 months/41.7 months (p<0.001), and the median progression-free survival (PFS) was 30/29.5/25 months (p=0.072), respectively.
Statistically significant difference in survival was confirmed among three ISS stages in thalidomide-based group, but not between ISS stages I and II in bortezomib-based group.
These findings suggest that ISS system can predict the survival in the era of novel agents in Chinese MM patients, and bortezomib may have the potential to partially overcome adverse effect of risk factors on survival, especially in higher stage of ISS system.
American Psychological Association (APA)
Lu, Jing& Lu, Jin& Liu, Aijun& Fu, Weijun& Du, Juan& Huang, Xiaojun…[et al.]. 2015. The Applicability of the International Staging System in Chinese Patients with Multiple Myeloma Receiving Bortezomib or Thalidomide-Based Regimens as Induction Therapy: A Multicenter Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057023
Modern Language Association (MLA)
Lu, Jing…[et al.]. The Applicability of the International Staging System in Chinese Patients with Multiple Myeloma Receiving Bortezomib or Thalidomide-Based Regimens as Induction Therapy: A Multicenter Analysis. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057023
American Medical Association (AMA)
Lu, Jing& Lu, Jin& Liu, Aijun& Fu, Weijun& Du, Juan& Huang, Xiaojun…[et al.]. The Applicability of the International Staging System in Chinese Patients with Multiple Myeloma Receiving Bortezomib or Thalidomide-Based Regimens as Induction Therapy: A Multicenter Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057023