Facial Characteristics and Olfactory Dysfunction: Two Endophenotypes Related to Nonsyndromic Cleft Lip andor Palate
Joint Authors
Devriendt, Koenraad
Roosenboom, J.
Saey, I.
Peeters, H.
Claes, P.
Hens, G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Evidence exists for the presence of a specific facial phenotype in nonaffected first-degree relatives of persons with CL/P.
An increased risk for olfactory dysfunction has also been reported in CL/P-relatives.
These phenotypic features can probably be explained via the presence of CL/P-related susceptibility genes.
We aimed at confirming the occurrence of these endophenotypic traits in first-degree CL/P-relatives, and we investigated the link between the facial phenotype and the smell capacity in this group.
We studied the facial morphology of 88 nonaffected first-degree relatives of patients with CL/P and 33 control subjects without family history of facial clefting by 3D surface imaging and a spatially dense analysis of the images.
Smell testing was performed in 30 relatives and compared with 23 control subjects.
Nonaffected relatives showed midface retrusion, hypertelorism, and olfactory dysfunction, compared to controls.
In addition, we show for the first time that olfactory dysfunction in relatives is correlated to a smaller upper nasal region.
This might be explained by a smaller central olfactory system.
The different facial morphology in the relatives with olfactory impairment as compared to the total group may be an illustration of the contribution of different genetic backgrounds to the occurrence of CL/P via different biological pathways.
American Psychological Association (APA)
Roosenboom, J.& Saey, I.& Peeters, H.& Devriendt, Koenraad& Claes, P.& Hens, G.. 2015. Facial Characteristics and Olfactory Dysfunction: Two Endophenotypes Related to Nonsyndromic Cleft Lip andor Palate. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057056
Modern Language Association (MLA)
Roosenboom, J.…[et al.]. Facial Characteristics and Olfactory Dysfunction: Two Endophenotypes Related to Nonsyndromic Cleft Lip andor Palate. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057056
American Medical Association (AMA)
Roosenboom, J.& Saey, I.& Peeters, H.& Devriendt, Koenraad& Claes, P.& Hens, G.. Facial Characteristics and Olfactory Dysfunction: Two Endophenotypes Related to Nonsyndromic Cleft Lip andor Palate. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057056