Phylogenetic and Ontogenetic View of Erythroblastic Islands
Joint Authors
Giger, Katie M.
Kalfa, Theodosia A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Erythroblastic islands are a hallmark of mammalian erythropoiesis consisting of a central macrophage surrounded by and interacting closely with the maturing erythroblasts.
The macrophages are thought to serve many functions such as supporting erythroblast proliferation, supplying iron for hemoglobin, promoting enucleation, and clearing the nuclear debris; moreover, inhibition of erythroblastic island formation is often detrimental to erythropoiesis.
There is still much not understood about the role that macrophages and microenvironment play in erythropoiesis and insights may be gleaned from a comparative analysis with erythropoietic niches in nonmammalian vertebrates which, unlike mammals, have erythrocytes that retain their nucleus.
The phylogenetic development of erythroblastic islands in mammals in which the erythrocytes are anucleate underlines the importance of the macrophage in erythroblast enucleation.
American Psychological Association (APA)
Giger, Katie M.& Kalfa, Theodosia A.. 2015. Phylogenetic and Ontogenetic View of Erythroblastic Islands. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057098
Modern Language Association (MLA)
Giger, Katie M.& Kalfa, Theodosia A.. Phylogenetic and Ontogenetic View of Erythroblastic Islands. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057098
American Medical Association (AMA)
Giger, Katie M.& Kalfa, Theodosia A.. Phylogenetic and Ontogenetic View of Erythroblastic Islands. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057098