Regulation of DEAHRHA Helicases by G-Patch Proteins
Joint Authors
Robert-Paganin, Julien
Réty, Stéphane
Leulliot, N.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
RNA helicases from the DEAH/RHA family are present in all the processes of RNA metabolism.
The function of two helicases from this family, Prp2 and Prp43, is regulated by protein partners containing a G-patch domain.
The G-patch is a glycine-rich domain discovered by sequence alignment, involved in protein-protein and protein-nucleic acid interaction.
Although it has been shown to stimulate the helicase’s enzymatic activities, the precise role of the G-patch domain remains unclear.
The role of G-patch proteins in the regulation of Prp43 activity has been studied in the two biological processes in which it is involved: splicing and ribosome biogenesis.
Depending on the pathway, the activity of Prp43 is modulated by different G-patch proteins.
A particular feature of the structure of DEAH/RHA helicases revealed by the Prp43 structure is the OB-fold domain in C-terminal part.
The OB-fold has been shown to be a platform responsible for the interaction with G-patch proteins and RNA.
Though there is still no structural data on the G-patch domain, in the current model, the interaction between the helicase, the G-patch protein, and RNA leads to a cooperative binding of RNA and conformational changes of the helicase.
American Psychological Association (APA)
Robert-Paganin, Julien& Réty, Stéphane& Leulliot, N.. 2015. Regulation of DEAHRHA Helicases by G-Patch Proteins. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057287
Modern Language Association (MLA)
Robert-Paganin, Julien…[et al.]. Regulation of DEAHRHA Helicases by G-Patch Proteins. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057287
American Medical Association (AMA)
Robert-Paganin, Julien& Réty, Stéphane& Leulliot, N.. Regulation of DEAHRHA Helicases by G-Patch Proteins. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057287