Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction
Joint Authors
Liu, Yue
Liu, Jiangang
Wang, Baojun
Shang, Qinghua
Zhang, Qingxiang
Shi, Dazhuo
Zhang, Lei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The objective of this study is to investigate the interaction of Panax quinquefolius saponin (PQS) and dual antiplatelets (aspirin and clopidogrel) on antiplatelet activity and vascular endothelial function in rats with acute myocardial infarction (AMI).
Forty-eight male SD rats were randomly designed into sham group, model group, dual antiplatelet group, and PQS plus dual antiplatelet group.
AMI rats were induced by ligation of left anterior descending coronary artery (LAD) and dual antiplatelet agents and additional PQS to dual antiplatelets were intragastrically administered for 28 days, respectively.
The ventricular cavity area and cardiac transverse area ratio in PQS + dual antiplatelet group showed a decreased tendency.
PAgT(%) decreased significantly in both dual antiplatelet group and PQS + dual antiplatelet group.
TXB2 concentration significantly decreased in dual antiplatelet and PQS + dual antiplatelet groups, whereas 6-keto-PGF1α concentration significantly increased in PQS + dual antiplatelet group.
Rats in PQS + dual antiplatelet group demonstrated a significant decrease in plasma ET-1 concentration and an increase in serum NO concentration compared with dual antiplatelet group.
The combination therapy of PQS and dual antiplatelets showed some beneficial effects on vascular endothelial function and ventricular remodeling in rats with AMI.
American Psychological Association (APA)
Wang, Baojun& Liu, Yue& Shang, Qinghua& Zhang, Qingxiang& Zhang, Lei& Liu, Jiangang…[et al.]. 2015. Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057290
Modern Language Association (MLA)
Wang, Baojun…[et al.]. Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057290
American Medical Association (AMA)
Wang, Baojun& Liu, Yue& Shang, Qinghua& Zhang, Qingxiang& Zhang, Lei& Liu, Jiangang…[et al.]. Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057290