Wntβ-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy
Joint Authors
Li, Jing
Ji, Ling
Chen, Jieping
Zhang, Wengeng
Ye, Zhijia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches throughout adult life.
Abnormal regulation of Wnt pathways leads to neoplastic proliferation in these tissues.
Recent research shows that Wnt signaling is also associated with the regulation of cancer stem cells (CSCs) through a similar mechanism to that observed in normal adult stem cells.
Thus, the Wnt/β-catenin signaling pathway has been intensively studied and characterized.
For this review, we will focus on the regulation of the Wnt/β-catenin signaling pathway in skin cancer.
With the important role in stemness and skin CSC proliferation, the Wnt/β-catenin signaling pathway and its elements have the potential to be targets for skin cancer therapy.
American Psychological Association (APA)
Li, Jing& Ji, Ling& Chen, Jieping& Zhang, Wengeng& Ye, Zhijia. 2015. Wntβ-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057407
Modern Language Association (MLA)
Li, Jing…[et al.]. Wntβ-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057407
American Medical Association (AMA)
Li, Jing& Ji, Ling& Chen, Jieping& Zhang, Wengeng& Ye, Zhijia. Wntβ-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057407