Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life
Joint Authors
Munoz-Tello, Paola
Rajappa, Lional
Coquille, Sandrine
Thore, Stéphane
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In eukaryotes, mRNA polyadenylation is a well-known modification that is essential for many aspects of the protein-coding RNAs life cycle.
However, modification of the 3′ terminal nucleotide within various RNA molecules is a general and conserved process that broadly modulates RNA function in all kingdoms of life.
Numerous types of modifications have been characterized, which are generally specific for a given type of RNA such as the CCA addition found in tRNAs.
In recent years, the addition of nontemplated uridine nucleotides or uridylation has been shown to occur in various types of RNA molecules and in various cellular compartments with significantly different outcomes.
Indeed, uridylation is able to alter RNA half-life both in positive and in negative ways, highlighting the importance of the enzymes in charge of performing this modification.
The present review aims at summarizing the current knowledge on the various processes leading to RNA 3′-end uridylation and on their potential impacts in various diseases.
American Psychological Association (APA)
Munoz-Tello, Paola& Rajappa, Lional& Coquille, Sandrine& Thore, Stéphane. 2015. Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057423
Modern Language Association (MLA)
Munoz-Tello, Paola…[et al.]. Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057423
American Medical Association (AMA)
Munoz-Tello, Paola& Rajappa, Lional& Coquille, Sandrine& Thore, Stéphane. Polyuridylation in Eukaryotes: A 3′-End Modification Regulating RNA Life. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057423