Recurrent Hepatocellular Carcinoma in Patient with Crohn’s Disease: Incidental or Expected Outcome of Azathioprine?
Joint Authors
Botros, Youssef
Mathews, Mary
Patel, Hiren
Shah, Nihar
de la Torre, Andrew
Baddoura, Walid
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) usually occurs in patients with underlying risk factors such as liver cirrhosis and chronic hepatitis B.
Although patients with Crohn’s disease (CD) are at an increased risk to develop malignancies such as colon cancer, the incidence of HCC in this population is extremely rare.
We report a case of 62-year-old male with long history of CD treated with azathioprine (AZA) and aminosalicylic acid (ASA) who was incidentally diagnosed with HCC, for which left hepatectomy was done.
Four years later during routine follow-up, patient had another hepatic lesion and underwent resection of the mass.
The mechanism of occurrence of HCC in patient with CD is still controversial and may include immune mediated changes and medication related complications.
AZA was reported in all case reports of CD that developed HCC.
Through this report we hope to explore the complex pathophysiological mechanisms contributing to the development of HCC in the Crohn’s disease patient population.
American Psychological Association (APA)
Botros, Youssef& Mathews, Mary& Patel, Hiren& Shah, Nihar& Baddoura, Walid& de la Torre, Andrew. 2015. Recurrent Hepatocellular Carcinoma in Patient with Crohn’s Disease: Incidental or Expected Outcome of Azathioprine?. Case Reports in Gastrointestinal Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058576
Modern Language Association (MLA)
Botros, Youssef…[et al.]. Recurrent Hepatocellular Carcinoma in Patient with Crohn’s Disease: Incidental or Expected Outcome of Azathioprine?. Case Reports in Gastrointestinal Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058576
American Medical Association (AMA)
Botros, Youssef& Mathews, Mary& Patel, Hiren& Shah, Nihar& Baddoura, Walid& de la Torre, Andrew. Recurrent Hepatocellular Carcinoma in Patient with Crohn’s Disease: Incidental or Expected Outcome of Azathioprine?. Case Reports in Gastrointestinal Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058576