Cerebral Amyloid Angiopathy-Related Inflammation: Report of a Case with Very Difficult Therapeutic Management
Joint Authors
Catalucci, Alessia
Crosta, Francesca
Orlandi, Berardino
De Santis, Federica
Passalacqua, Gianni
DiFrancesco, Jacopo C.
Piazza, Fabrizio
Desideri, Giovambattista
Marini, Carmine
Source
Case Reports in Neurological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Cerebral amyloid angiopathy-related inflammation (CAA-ri) results from autoimmune response to beta-amyloid deposits in cerebral vessels.
Its clinical course and complications have seldom been described in literature.
Case Report.
In a patient presenting with delirium and left hemiparesis the diagnosis of CAA-ri was supported by the finding of elevated anti-amyloid autoantibodies in the cerebrospinal fluid (CSF).
Steroid therapy produced significant improvements in clinical and investigational assessments, but after two months, it caused Acute Respiratory Distress Syndrome.
After steroid therapy discontinuation the patient presented a rapidly progressive dementia, Guillain-Barré syndrome, new cerebral ischemic lesions, and thrombosis of the right cephalic and subclavian veins that were treated with subcutaneous heparin.
After a week the patient died because of brain hemorrhage.
Conclusion.
This case suggests caution in steroid therapy discontinuation and antithrombotic therapy administration in patients with CAA-ri.
The CSF search of anti-amyloid autoantibodies could be helpful to support the diagnosis.
American Psychological Association (APA)
Crosta, Francesca& Orlandi, Berardino& De Santis, Federica& Passalacqua, Gianni& DiFrancesco, Jacopo C.& Piazza, Fabrizio…[et al.]. 2015. Cerebral Amyloid Angiopathy-Related Inflammation: Report of a Case with Very Difficult Therapeutic Management. Case Reports in Neurological Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059036
Modern Language Association (MLA)
Crosta, Francesca…[et al.]. Cerebral Amyloid Angiopathy-Related Inflammation: Report of a Case with Very Difficult Therapeutic Management. Case Reports in Neurological Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059036
American Medical Association (AMA)
Crosta, Francesca& Orlandi, Berardino& De Santis, Federica& Passalacqua, Gianni& DiFrancesco, Jacopo C.& Piazza, Fabrizio…[et al.]. Cerebral Amyloid Angiopathy-Related Inflammation: Report of a Case with Very Difficult Therapeutic Management. Case Reports in Neurological Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059036