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Lymphocyte-Predominant Hodgkin’s Disease in Children: A Case Study and Review of the Literature
Joint Authors
Stier, James R.
Vasquez, Robert J.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A three-year-old boy presented with an enlarging neck mass.
Biopsy demonstrated IgD-positive nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), which was staged as IIa.
The patient received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab and had excellent results.
NLPHL is a relatively rare disease that is biologically distinct from classic Hodgkin lymphoma (cHL).
NLPHL is a B-cell malignancy likely of germinal center origin that has an overall good prognosis and favorable response to treatment.
Unlike cHL, NLPHL is ubiquitously CD20-positive.
Recent evidence supports the efficacy of targeted anti-CD20 therapy in NLPHL, though prospective data is limited.
This case demonstrates several unique features of NLPHL and further supports the use of rituximab in front-line therapy.
The clinical characteristics among patients at various ages are discussed with a special focus on the IgD-positive subtype.
A thorough literature search demonstrates this to be the youngest patient with NLPHL yet described.
American Psychological Association (APA)
Stier, James R.& Vasquez, Robert J.. 2015. Lymphocyte-Predominant Hodgkin’s Disease in Children: A Case Study and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059268
Modern Language Association (MLA)
Stier, James R.& Vasquez, Robert J.. Lymphocyte-Predominant Hodgkin’s Disease in Children: A Case Study and Review of the Literature. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059268
American Medical Association (AMA)
Stier, James R.& Vasquez, Robert J.. Lymphocyte-Predominant Hodgkin’s Disease in Children: A Case Study and Review of the Literature. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059268