Activated Complement Factors as Disease Markers for Sepsis
Joint Authors
Charchaflieh, Jean
Rushbrook, Julie
Worah, Samrat
Zhang, Ming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sepsis is a leading cause of death in the United States and worldwide.
Early recognition and effective management are essential for improved outcome.
However, early recognition is impeded by lack of clinically utilized biomarkers.
Complement factors play important roles in the mechanisms leading to sepsis and can potentially serve as early markers of sepsis and of sepsis severity and outcome.
This review provides a synopsis of recent animal and clinical studies of the role of complement factors in sepsis development, together with their potential as disease markers.
In addition, new results from our laboratory are presented regarding the involvement of the complement factor, mannose-binding lectin, in septic shock patients.
Future clinical studies are needed to obtain the complete profiles of complement factors/their activated products during the course of sepsis development.
We anticipate that the results of these studies will lead to a multipanel set of sepsis biomarkers which, along with currently used laboratory tests, will facilitate earlier diagnosis, timely treatment, and improved outcome.
American Psychological Association (APA)
Charchaflieh, Jean& Rushbrook, Julie& Worah, Samrat& Zhang, Ming. 2015. Activated Complement Factors as Disease Markers for Sepsis. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060925
Modern Language Association (MLA)
Charchaflieh, Jean…[et al.]. Activated Complement Factors as Disease Markers for Sepsis. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060925
American Medical Association (AMA)
Charchaflieh, Jean& Rushbrook, Julie& Worah, Samrat& Zhang, Ming. Activated Complement Factors as Disease Markers for Sepsis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060925