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Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis
Joint Authors
Niu, Yu-Ming
Weng, Hong
Zhang, Chao
Hu, Yuan-Yuan
Yuan, Rui-Xia
Zuo, Hong-Xia
Yan, Jin-Zhu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Certain studies have previously explored the association between the estrogen receptor-α (ER-α) gene polymorphisms and periodontitis susceptibility, although the current results are controversial.
The present study, using meta-analysis, aimed to investigate the nature of the genetic susceptibility of the ER-α for developing periodontitis.
Methods.
A comprehensive literature search of PubMed, Embase, CNKI, and Wanfang databases was conducted up to January 8, 2015.
Statistical manipulation was performed using Stata version 13.0 software.
Odds ratios (ORs) and corresponding 95% confident intervals (CIs) were calculated to estimate the association in five genetic models.
Results.
A total of 17 eligible case-control studies from seven identified publications consisting of nine studies for the XbaI polymorphism and eight studies for the PvuII polymorphism were included in the meta-analysis.
We found elevated risk of periodontitis in XbaI XX genotype carriers.
Moreover, subgroup analyses demonstrated increased risk for chronic periodontitis of XbaI XX genotype carriers, specifically in the Chinese Han female population.
No significant association was observed between PvuII polymorphism and periodontitis.
Conclusion.
Current evidence indicated that the homozygote (XX) genotype of ER-α gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.
American Psychological Association (APA)
Weng, Hong& Zhang, Chao& Hu, Yuan-Yuan& Yuan, Rui-Xia& Zuo, Hong-Xia& Yan, Jin-Zhu…[et al.]. 2015. Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061025
Modern Language Association (MLA)
Weng, Hong…[et al.]. Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061025
American Medical Association (AMA)
Weng, Hong& Zhang, Chao& Hu, Yuan-Yuan& Yuan, Rui-Xia& Zuo, Hong-Xia& Yan, Jin-Zhu…[et al.]. Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061025