The Effect of Depression on Serum VEGF Level in Alzheimer’s Disease
Joint Authors
Jung, JaeHoon
Kim, SoYeon
Yoon, KyungHee
Moon, YooSun
Roh, Daeyoung
Lee, SangKyu
Choi, KyungChan
Jung, JunSub
Kim, DoHoon
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Growing evidence suggests that angiogenesis might represent a new pathogenic mechanism involved in the progression of Alzheimer’s disease (AD).
Among angiogenic cytokines, vascular endothelial growth factor (VEGF) levels in AD patients have been evaluated, but the results are controversial among studies.
We investigated serum levels of VEGF in AD patients with depression, AD patients without depression, and the controls, respectively.
The aim of this study is to elucidate the relationship between VEGF, depression, and cognitive impairment in AD.
Methods.
The CDR (Clinical Dementia Rating), MMSE-KC (the Mini-Mental Status Examination-Korean version), and SGDS-K (the Korean version of the Geriatric Depression Scale-Short Form) were measured in the subjects.
Serum VEGF levels were measured in 24 AD patients with depression, 25 AD patients without depression, and 26 controls, using an enzyme-linked immunosorbent assay kit.
Results.
Serum VEGF levels in AD patients with depression were significantly higher than AD patients without depression or the control.
A correlation was observed between VEGF and scores on SGDS-K, but no correlation was detected between VEGF and MMSE-KC scores.
Conclusion.
Serum VEGF levels in AD patients with depression were higher than those without depression.
Depression might be associated with changes in serum levels of VEGF in AD patients.
American Psychological Association (APA)
Jung, JaeHoon& Kim, SoYeon& Yoon, KyungHee& Moon, YooSun& Roh, Daeyoung& Lee, SangKyu…[et al.]. 2015. The Effect of Depression on Serum VEGF Level in Alzheimer’s Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061026
Modern Language Association (MLA)
Jung, JaeHoon…[et al.]. The Effect of Depression on Serum VEGF Level in Alzheimer’s Disease. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061026
American Medical Association (AMA)
Jung, JaeHoon& Kim, SoYeon& Yoon, KyungHee& Moon, YooSun& Roh, Daeyoung& Lee, SangKyu…[et al.]. The Effect of Depression on Serum VEGF Level in Alzheimer’s Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061026