Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with AmlodipineBenazepril or ValsartanHydrochlorothiazide
Joint Authors
Chen, Jung-Fu
Lee, I-Te
Wang, Chih-Yuan
Lee, Wen-Jane
Hung, Yi-Jen
Sheu, Wayne Huey-Herng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation.
However, the effects of BDNF on diabetic nephropathy are unknown.
The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications.
Methods.
In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period.
The post hoc analyses were based on increased or decreased serum BDNF levels.
Results.
Of the 153 enrolled subjects, the changes in eGFR were significantly and inversely correlated with those in BDNF in the 76 subjects treated with valsartan/hydrochlorothiazide (r=-0.264, P=0.021) but not in the 77 subjects treated with benazepril/amlodipine (r=-0.025, P=0.862).
The 45 subjects with increased BDNF following valsartan/hydrochlorothiazide treatment exhibited a significantly reduced eGFR (-8.8±14.9 mL/min/1.73 m2; P<0.001).
Multivariate regression analysis revealed that increased serum BDNF represents an independent factor for reduced eGFR (95% confidence interval between −0.887 and −0.076, P=0.020).
Conclusions.
Increased serum BDNF is associated with reduced eGFR in type 2 diabetic subjects treated with valsartan/hydrochlorothiazide but not with amlodipine/benazepril.
American Psychological Association (APA)
Lee, I-Te& Sheu, Wayne Huey-Herng& Hung, Yi-Jen& Chen, Jung-Fu& Wang, Chih-Yuan& Lee, Wen-Jane. 2015. Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with AmlodipineBenazepril or ValsartanHydrochlorothiazide. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061038
Modern Language Association (MLA)
Lee, I-Te…[et al.]. Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with AmlodipineBenazepril or ValsartanHydrochlorothiazide. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061038
American Medical Association (AMA)
Lee, I-Te& Sheu, Wayne Huey-Herng& Hung, Yi-Jen& Chen, Jung-Fu& Wang, Chih-Yuan& Lee, Wen-Jane. Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with AmlodipineBenazepril or ValsartanHydrochlorothiazide. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061038