Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis
Joint Authors
Dong, Shu
Su, Shi-Bing
Chen, Qi-long
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The Fuzheng Huayu (FZHY) formula is being used in antiliver fibrosis treatment in China.
For systemic evaluation of the curative effects of FZHY on liver fibrosis and cirrhosis progress, a total of 1392 subjects (714 cases and 678 controls) were found to be eligible for meta-analysis in this study.
Standard mean differences (SMDs) with 95% confidence interval (CI) were calculated for changes between FZHY groups and controls by employing fixed effects or random effects model.
In the overall analysis, alanine transaminase (ALT) (P=0.003, SMD = −0.87, 95% CI: −1.46 to −0.29), total bilirubin (TBil) (P=0.001, SMD = −1.30, 95% CI: −2.10 to −0.50), hyaluronic acid (HA) (P=0.000, SMD = −0.94, 95% CI: −1.30 to −0.58), laminin (LN) (P=0.000, SMD = −0.80, 95% CI: −1.20 to −0.41), type III procollagen (PC-III) (P=0.000, SMD = −1.27, 95% CI: −1.93 to −0.60), and type IV procollagen (IV-C) (P=0.000, SMD = −0.78, 95% CI: −1.05 to −0.51) were decreased after FZHY treatment; however, albumin (ALB) was increased (P=0.037, SMD = 1.10, 95% CI: 0.07 to 2.12) significantly.
Furthermore, the Child-Pugh score was reduced significantly and the life quality was improved after FZHY treatment in cirrhosis patients.
The results of this meta-analysis indicated that FZHY effectively improves the liver function, alleviates hepatic fibrosis, decreases Child-Pugh score, and relieves TCM symptoms caused by liver dysfunction, indicating that FZHY may contribute to the alleviation of liver fibrosis and cirrhosis.
American Psychological Association (APA)
Dong, Shu& Chen, Qi-long& Su, Shi-Bing. 2015. Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061151
Modern Language Association (MLA)
Dong, Shu…[et al.]. Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061151
American Medical Association (AMA)
Dong, Shu& Chen, Qi-long& Su, Shi-Bing. Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061151