Neuroprotective Effect of Radix Trichosanthis Saponins on Subarachnoid Hemorrhage
Joint Authors
Chen, Ying
Sun, Haiyan
Huang, Liyong
Li, Juxiang
Zhou, Wenke
Chang, Jingling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Redox homeostasis has been implicated in subarachnoid hemorrhage (SAH).
As a result, antioxidants and/or free radical scavengers have become an important therapeutic modality.
Considering that radix trichosanthis (RT) saponins exhibited strong antioxidant ability both in vivo and in vitro, the present study aimed to reveal whether the neuroprotective activities of RT saponins were mediated by p38/p53 signal pathway after SAH.
An established SAH model was used and superoxide dismutase (SOD), malondialdehyde (MDA), induced nitric oxide synthase (iNOS), nitric oxide (NO), lactate dehydrogenase (LDH), p-p38, and p53 activation were detected after 48 h of SAH.
The results showed that RT saponins inhibited iNOS expression to restore NO to basal level.
Moreover, compared with Cu/Zn-SOD, RT saponins (2 mg/kg/d dosage) significantly increased Mn-SOD activity after SAH.
Accompanied with lowered NO and elevated SOD, decreased p38 phosphorylation and p53 activities were observed, especially for RT saponins at 2 mg/kg/d dosage.
In this setting, the neurological outcome was also improved with less neuronal cells damage after RT saponins pretreatment.
Our findings demonstrated the beneficial effects of RT saponins in enhancing neuroprotective effects by deducing iNOS activity, normalizing SOD level, and inhibiting p-p38 and p53 expression, hence offering significant therapeutic implications for SAH.
American Psychological Association (APA)
Chen, Ying& Sun, Haiyan& Huang, Liyong& Li, Juxiang& Zhou, Wenke& Chang, Jingling. 2015. Neuroprotective Effect of Radix Trichosanthis Saponins on Subarachnoid Hemorrhage. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061342
Modern Language Association (MLA)
Chen, Ying…[et al.]. Neuroprotective Effect of Radix Trichosanthis Saponins on Subarachnoid Hemorrhage. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061342
American Medical Association (AMA)
Chen, Ying& Sun, Haiyan& Huang, Liyong& Li, Juxiang& Zhou, Wenke& Chang, Jingling. Neuroprotective Effect of Radix Trichosanthis Saponins on Subarachnoid Hemorrhage. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061342