Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats
Joint Authors
Gu, You-you
Wang, Huan
Wang, Su
Gao, Hua
Qiu, Ming-cai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the effect of Cordyceps sinensis (CS) on the expressions of NF-κB and TGF-β1 in myocardium of streptozotocin-induced diabetic rats.
Methods.
A total of 53 healthy male SD rats, mice age of 8 weeks and weight of 220 ± 20 g, were randomly divided into five groups by randomized block design: normal control group (n=10), diabetic group (n=10), low dose of CS group (n=12; CS 0.6 g·kg−1·d−1), middle dose of CS group (n=11; CS 2.5 g·kg−1·d−1), and high dose of CS group (n=10; CS 5 g·kg−1·d−1).
The diabetic models with tail intravenous injection by streptozotocin (45 mg·kg−1).
Diabetic rats were sacrificed after 8 weeks; the expressions of NF-κB and TGF-β1 proteins and mRNA in the cardiac muscle were determined by using immunohistochemistry staining and reverse transcription polymerase chain reaction (RT-PCR) method.
The data were analyzed using one factor analysis of variance.
Result.
The expressions of NF-κB and TGF-β1 proteins and mRNA in the cardiac muscle of diabetic rats were significantly raised (P<0.05), which could be decreased by CS (P<0.05).
Conclusions.
The changes on the expressions of NF-κB and TGF-β1 in myocardium may be involved in the occurrence of diabetic cardiomyopathy (DC).
CS may play its role on myocardial protection by regulating the expressions of NF-κB and TGF-β1 in myocardium.
American Psychological Association (APA)
Gu, You-you& Wang, Huan& Wang, Su& Gao, Hua& Qiu, Ming-cai. 2015. Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061420
Modern Language Association (MLA)
Gu, You-you…[et al.]. Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061420
American Medical Association (AMA)
Gu, You-you& Wang, Huan& Wang, Su& Gao, Hua& Qiu, Ming-cai. Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061420