The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model
Joint Authors
Adilijiang, Abulimiti
Guan, Teng
He, Jue
Hartle, Kelly
Wang, Wenqiang
Li, XinMin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Schizophrenia is a serious psychiatric illness with an unclear cause.
One theory is that demyelination of white matter is one of the main pathological factors involved in the development of schizophrenia.
The current study evaluated the protective effects of Areca catechu nut extract (ANE) on a cuprizone-induced demyelination mouse model.
Two doses of ANE (1% and 2%) were administered orally in the diet for 8 weeks.
Animals subjected to demyelination showed impaired spatial memory and less social activity.
In addition, mice subjected to demyelination displayed significant myelin damage in cortex and demonstrated a higher expression of NG2 and PDGFRα and AMPK activation.
ANE treatment not only significantly enhanced cognitive ability and social activity, but also protected myelin against cuprizone toxicity by promoting oligodendrocyte precursor cell (OPC) differentiation.
In addition, ANE treatment demonstrated significant dephosphorylation of AMPKα, indicating a regulatory role for ANE in schizophrenia.
This study showed that ANE treatment may enhance cognitive ability and social activity by facilitating OPC differentiation and protecting against myelin damage in cortex.
Results also suggest the AMPK signaling pathway may be involved in this process.
American Psychological Association (APA)
Adilijiang, Abulimiti& Guan, Teng& He, Jue& Hartle, Kelly& Wang, Wenqiang& Li, XinMin. 2015. The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061491
Modern Language Association (MLA)
Adilijiang, Abulimiti…[et al.]. The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061491
American Medical Association (AMA)
Adilijiang, Abulimiti& Guan, Teng& He, Jue& Hartle, Kelly& Wang, Wenqiang& Li, XinMin. The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061491