Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models
Joint Authors
Fu, Feng-hua
Li, Minmin
Lu, Chengwen
Du, Yuan
Duan, Sijin
Wang, Tian
Zhang, Lei-Ming
Zhang, Jianqiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models.
The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed.
It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2.
In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice.
These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.
American Psychological Association (APA)
Li, Minmin& Lu, Chengwen& Zhang, Lei-Ming& Zhang, Jianqiao& Du, Yuan& Duan, Sijin…[et al.]. 2015. Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061568
Modern Language Association (MLA)
Li, Minmin…[et al.]. Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061568
American Medical Association (AMA)
Li, Minmin& Lu, Chengwen& Zhang, Lei-Ming& Zhang, Jianqiao& Du, Yuan& Duan, Sijin…[et al.]. Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061568
