Bavachalcone Enhances RORα Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells
Joint Authors
Ni, Rong-Zhen
Dang, Yanqi
Ma, Jing
Ling, Shuang
Xu, Jin-Wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The circadian clock regulates many aspects of (patho)physiology in the central nervous system and in the peripheral tissues.
RAR-related orphan receptor α (RORα), an orphan nuclear receptor, is involved in circadian rhythm regulation, including regulation of cardiovascular function.
Bavachalcone, a prenylchalcone, is a major bioactive chalcone isolated from Psoralea corylifolia.
This natural ingredient activated RORα1 luciferase reporter activity on drug screening.
In addition, bavachalcone induced RORα1 expression in mRNA and protein levels in a dose-dependent manner and enhanced the circadian amplitude of Bmal1 mRNA expression after serum shock.
Moreover, bavachalcone suppressed senescence in human endothelial cells and mRNA expression of p16ink4a (a marker of replicative senescence) and IL-1α (a proinflammatory cytokine of the senescence-associated secretory phenotype).
These inhibitory effects were partially reversed by the RORα inhibitor VPR-66.
Our results demonstrate that bavachalcone, as a natural medicine ingredient, has a pharmacological function in regulating RORα1.
American Psychological Association (APA)
Dang, Yanqi& Ling, Shuang& Ma, Jing& Ni, Rong-Zhen& Xu, Jin-Wen. 2015. Bavachalcone Enhances RORα Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063803
Modern Language Association (MLA)
Dang, Yanqi…[et al.]. Bavachalcone Enhances RORα Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063803
American Medical Association (AMA)
Dang, Yanqi& Ling, Shuang& Ma, Jing& Ni, Rong-Zhen& Xu, Jin-Wen. Bavachalcone Enhances RORα Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063803