Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study
Joint Authors
Magnani, Giulia
Furlan, Daniela
Sahnane, Nora
Reggiani Bonetti, Luca
Domati, Federica
Pedroni, Monica
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Colorectal cancer is usually considered a disease of the elderly.
However, a small fraction of patients develops colorectal cancer earlier.
The aim of our study was to define the frequency of known hereditary colorectal syndromes and to characterise genetic and epigenetic features of early nonhereditary tumors.
Thirty-three patients ≤40 years with diagnosis of colorectal cancer and 41 patients with disease at >60 years of age were investigated for MSI, Mismatch Repair proteins expression, KRAS and BRAF mutations, hypermethylation, and LINE-1 hypomethylation.
Detection of germline mutations was performed in Mismatch Repair, APC and MUTYH genes.
Early onset colorectal cancer showed a high incidence of hereditary forms (18%).
KRAS mutations were detected in 36% of early nonhereditary tumors.
Early onset colorectal cancer disclosed an average number of methylated genes significantly lower when compared to the controls (p=0.02).
Finally both of the two groups were highly methylated in ESR1, GATA5, and WT1 genes and were similar for LINE-1 hypomethylation.
The genetic make-up of carcinomas differs from young to elderly patients.
Early onset tumors showed more frequently a constitutional defective of Mismatch Repair System and a minor number of methylated genes.
Hypermethylation of ESR1, GATA5, and WT1 genes suggests possible markers in the earlier diagnosis of colorectal tumorigenesis.
American Psychological Association (APA)
Magnani, Giulia& Furlan, Daniela& Sahnane, Nora& Reggiani Bonetti, Luca& Domati, Federica& Pedroni, Monica. 2015. Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063919
Modern Language Association (MLA)
Magnani, Giulia…[et al.]. Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063919
American Medical Association (AMA)
Magnani, Giulia& Furlan, Daniela& Sahnane, Nora& Reggiani Bonetti, Luca& Domati, Federica& Pedroni, Monica. Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063919