Site-Specific Immunomodulator: A Novel Treatment for Crohn’s Disease
Joint Authors
Bressler, Brian
Bethel, Kevin P.
Kleef, Ralf
Reynolds, Sophie L.
Sutcliffe, Simon
Mullins, David W.
Gunn, Hal
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the mechanism of action, safety, and efficacy of the Site-Specific Immunomodulator (SSI) QBECO, a novel immunotherapy for Crohn’s disease (CD).
Using human monocytic THP-1 cells, we demonstrate that SSI QBECO (derived from the common colon bacteria E.
coli) activates macrophages to an M1 phenotype (associated with enhanced capacity to eliminate bacteria and activate innate immune responses).
We assessed SSI QBECO in a compassionate use protocol of ten adult patients with active CD.
Patients with moderate to severe clinical symptoms receiving conventional CD treatments and/or complementary therapies were included, except patients receiving anti-TNF medications.
SSI QBECO was self-administered subcutaneously every second day, for a minimum of 2.5 months and a maximum of 11 months.
All 10 patients reported improvement of symptoms while on the SSI QBECO treatment.
Seven patients reported full resolution of clinical symptoms during a course of SSI QBECO of at least three months.
Three patients have experienced ongoing sustained clinical remission after discontinuing all medications, including SSI treatment.
The longest case of clinical remission is still ongoing (>4 years).
No serious severe adverse clinical events were reported.
Collectively, we conclude that treatment with the immunoactive SSI QBECO was well tolerated and effective for treatment of Crohn’s disease in this case series.
American Psychological Association (APA)
Bressler, Brian& Bethel, Kevin P.& Kleef, Ralf& Reynolds, Sophie L.& Sutcliffe, Simon& Mullins, David W.…[et al.]. 2015. Site-Specific Immunomodulator: A Novel Treatment for Crohn’s Disease. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063937
Modern Language Association (MLA)
Bressler, Brian…[et al.]. Site-Specific Immunomodulator: A Novel Treatment for Crohn’s Disease. Gastroenterology Research and Practice No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063937
American Medical Association (AMA)
Bressler, Brian& Bethel, Kevin P.& Kleef, Ralf& Reynolds, Sophie L.& Sutcliffe, Simon& Mullins, David W.…[et al.]. Site-Specific Immunomodulator: A Novel Treatment for Crohn’s Disease. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063937