Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection
Joint Authors
Gesualdo, Michele
Ciccone, Marco Matteo
Di Leo, Alfredo
Brunetti, Natale Daniele
Barone, Michele
Viggiani, Maria Teresa
Amoruso, Annabianca
Schiraldi, Serafina
Devito, Fiorella
Zito, Annapaola
Cortese, Francesca
Scicchitano, Pietro
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver.
Aims.
To clarify the role of HCV in atherosclerosis development in monoinfected HCV patients at different degrees of liver fibrosis and with no risk factors for coronary artery disease.
Methods.
Forty-five patients were included.
Clinical, serological, and anthropometric parameters, liver fibrosis (transient liver elastometry (fibroscan) and aspartate aminotransferase to platelet ratio index (APRI)), carotid intima-media thickness (c-IMT), and brachial artery flow-mediated vasodilatation (FMD) were assessed.
Patients were divided into 3 tertiles according to fibroscan values.
Results.
Patients in the third tertile (fibroscan value >11.5 KPa) showed FMD values were significantly lower than second and first tertiles ( 4.7 ± 1.7 % versus 7.1 ± 2.8 % , p = 0.03 ).
FMD values were inversely related to liver elastomeric values.
c-IMT values were normal.
The risk for endothelial dysfunction development in the third tertile ( p = 0.02 ) was 6.9 higher than the first tertile.
A fibroscan value >11.5 KPa had a positive predictive power equal to 79% for endothelial dysfunction.
Conclusions.
HCV advanced liver fibrosis promotes atherosclerosis by inducing endothelial dysfunction independently of common cardiovascular risk factors.
American Psychological Association (APA)
Barone, Michele& Viggiani, Maria Teresa& Amoruso, Annabianca& Schiraldi, Serafina& Zito, Annapaola& Devito, Fiorella…[et al.]. 2015. Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064086
Modern Language Association (MLA)
Barone, Michele…[et al.]. Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection. Gastroenterology Research and Practice No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1064086
American Medical Association (AMA)
Barone, Michele& Viggiani, Maria Teresa& Amoruso, Annabianca& Schiraldi, Serafina& Zito, Annapaola& Devito, Fiorella…[et al.]. Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064086