Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer
Joint Authors
Inokuchi, Mikito
Fujimori, Yoshitaka
Otsuki, Sho
Sato, Yuya
Nakagawa, Masatoshi
Kojima, Kazuyuki
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable.
Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed, and monoclonal antibodies targeting human epidermal growth factor receptor 2 (HER2) have become standard therapy for HER2-positive GC.
An inhibitor of vascular endothelial growth factor receptor 2 or MET has also produced promising results in patients with GC.
Fibroblast growth factor receptors (FGFR) play key roles in tumor growth via activated signaling pathways in GC.
Genomic amplification of FGFR2 leads to the aberrant activation found in GC tumors and is related to survival in patients with GC.
This review discusses the clinical relevance of FGFR in GC and examines FGFR as a potential therapeutic target in patients with GC.
Preclinical studies in animal models suggest that multitargeted tyrosine kinase inhibitors (TKIs), including FGFR inhibitor, suppress tumor cell proliferation and delay tumor progression.
Several TKIs are now being evaluated in clinical trials as treatment for metastatic or unresectable GC harboring FGFR2 amplification.
American Psychological Association (APA)
Inokuchi, Mikito& Fujimori, Yoshitaka& Otsuki, Sho& Sato, Yuya& Nakagawa, Masatoshi& Kojima, Kazuyuki. 2015. Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064118
Modern Language Association (MLA)
Inokuchi, Mikito…[et al.]. Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064118
American Medical Association (AMA)
Inokuchi, Mikito& Fujimori, Yoshitaka& Otsuki, Sho& Sato, Yuya& Nakagawa, Masatoshi& Kojima, Kazuyuki. Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064118