MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis
Joint Authors
Halkova, Tereza
Cuperkova, Romana
Minarik, Marek
Benesova, Lucie
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pancreatic cancer is one of the most fatal malignancies with increasing incidence and high mortality.
Possibilities for early diagnosis are limited and there is currently no efficient therapy.
Molecular markers that have been introduced into diagnosis and treatment of other solid tumors remain unreciprocated in this disease.
Recent discoveries have shown that certain microRNAs (miRNAs) take part in fundamental molecular processes associated with pancreatic cancer initiation and progression including cell cycle, DNA repair, apoptosis, invasivity, and metastasis.
The mechanism involves both positive and negative regulation of expression of protooncogenes and tumor suppressor genes.
Various miRNAs are expressed at different levels among normal pancreatic tissue, chronic pancreatitis, and pancreatic cancer and may therefore serve as a tool to differentiate chronic pancreatitis from early stages of cancer.
Other miRNAs can indicate the probable course of the disease or determine the survival prognosis.
In addition, there is a growing interest directed at the understanding of miRNA-induced molecular mechanisms.
The possibility of intervention in the molecular mechanisms of miRNAs regulation could begin a new generation of pancreatic cancer therapies.
This review summarizes the recent reports describing functions of miRNAs in cellular processes underlying pancreatic cancerogenesis and their utility in diagnosis, survival prognosis, and therapy.
American Psychological Association (APA)
Halkova, Tereza& Cuperkova, Romana& Minarik, Marek& Benesova, Lucie. 2015. MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064143
Modern Language Association (MLA)
Halkova, Tereza…[et al.]. MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1064143
American Medical Association (AMA)
Halkova, Tereza& Cuperkova, Romana& Minarik, Marek& Benesova, Lucie. MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064143