From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal Cancer
Joint Authors
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Histological classification of adenocarcinoma or squamous cell carcinoma for esophageal cancer or using the Lauren classification for intestinal and diffuse type gastric cancer has limited clinical utility in the management of advanced disease.
Germline mutations in E-cadherin (CDH1) or mismatch repair genes (Lynch syndrome) were identified many years ago but given their rarity, the identification of these molecular alterations does not substantially impact treatment in the advanced setting.
Recent molecular profiling studies of upper GI tumors have added to our knowledge of the underlying biology but have not led to an alternative classification system which can guide clinician’s therapeutic decisions.
Recently the Cancer Genome Atlas Research Network has proposed four subtypes of gastric cancer dividing tumors into those positive for Epstein-Barr virus, microsatellite unstable tumors, genomically stable tumors, and tumors with chromosomal instability.
Unfortunately to date, many phase III clinical trials involving molecularly targeted agents have failed to meet their survival endpoints due to their use in unselected populations.
Future clinical trials should utilize molecular profiling of individual tumors in order to determine the optimal use of targeted therapies in preselected patients.
American Psychological Association (APA)
Murphy, Adrian& Kelly, Ronan J.. 2015. From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal Cancer. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064145
Modern Language Association (MLA)
Murphy, Adrian& Kelly, Ronan J.. From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal Cancer. Gastroenterology Research and Practice No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1064145
American Medical Association (AMA)
Murphy, Adrian& Kelly, Ronan J.. From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal Cancer. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064145