Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity

Joint Authors

Singh, Prabhakar
Rizvi, Syed Ibrahim

Source

International Journal of Cell Biology

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-09-02

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Biology

Abstract EN

Curcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the yellow biphenolic pigment isolated from turmeric (Curcuma longa), has various medicinal benefits through antioxidation, anti-inflammation, cardiovascular protection, immunomodulation, enhancing of the apoptotic process, and antiangiogenic property.

We explored the effects of curcumin in vitro (10−5 M to 10−8 M) and in vivo (340 and 170 mg/kg b.w., oral) on Na+/K+ ATPase (NKA), Na+/H+ exchanger (NHE) activity, and membrane lipid hydroperoxides (ROOH) in control and experimental oxidative stress erythrocytes of Wistar rats.

As a result, we found that curcumin potently modulated the membrane transporters activity with protecting membrane lipids against hydro-peroxidation in control as well as oxidatively challenged erythrocytes evidenced by stimulation of NKA, downregulation of NHE, and reduction of ROOH in the membrane.

The observed results corroborate membrane transporters activity with susceptibility of erythrocyte membrane towards oxidative damage.

Results explain the protective mechanism of curcumin against oxidative stress mediated impairment in ions-transporters activity and health beneficial effects.

American Psychological Association (APA)

Singh, Prabhakar& Rizvi, Syed Ibrahim. 2015. Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065334

Modern Language Association (MLA)

Singh, Prabhakar& Rizvi, Syed Ibrahim. Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity. International Journal of Cell Biology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065334

American Medical Association (AMA)

Singh, Prabhakar& Rizvi, Syed Ibrahim. Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065334

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1065334