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CEBPβ Isoforms Expression in the Rat Brain during the Estrous Cycle
Joint Authors
Camacho-Arroyo, Ignacio
Hansberg-Pastor, Valeria
Piña-Medina, Ana Gabriela
González-Arenas, Aliesha
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The CCAAT/enhancer-binding protein beta (C/EBPβ) is a transcription factor expressed in different areas of the brain that regulates the expression of several genes involved in cell differentiation and proliferation.
This protein has three isoforms (LAP1, LAP2, and LIP) with different transcription activation potential.
The role of female sex hormones in the expression pattern of C/EBPβ isoforms in the rat brain has not yet been described.
In this study we demonstrate by western blot that the expression of the three C/EBPβ isoforms changes in different brain areas during the estrous cycle.
In the cerebellum, LAP2 content diminished on diestrus and proestrus and LIP content diminished on proestrus and estrus days.
In the prefrontal cortex, LIP content was higher on proestrus and estrus days.
In the hippocampus, LAP isoforms presented a switch on diestrus day, since LAP1 content was the highest while that of LAP2 was the lowest.
The LAP2 isoform was the most abundant one in all the three brain areas.
The LAP/LIP ratio changed throughout the cycle and was tissue specific.
These results suggest that C/EBPβ isoforms expression changes in a tissue-specific manner in the rat brain due to the changes in sex steroid hormone levels presented during the estrous cycle.
American Psychological Association (APA)
Hansberg-Pastor, Valeria& Piña-Medina, Ana Gabriela& González-Arenas, Aliesha& Camacho-Arroyo, Ignacio. 2015. CEBPβ Isoforms Expression in the Rat Brain during the Estrous Cycle. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065775
Modern Language Association (MLA)
Hansberg-Pastor, Valeria…[et al.]. CEBPβ Isoforms Expression in the Rat Brain during the Estrous Cycle. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065775
American Medical Association (AMA)
Hansberg-Pastor, Valeria& Piña-Medina, Ana Gabriela& González-Arenas, Aliesha& Camacho-Arroyo, Ignacio. CEBPβ Isoforms Expression in the Rat Brain during the Estrous Cycle. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065775