Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia
Joint Authors
Zheng, Rendong
Liu, Kemian
Chen, Kun
Cao, Wen
Cao, Lin
Zhang, Huifeng
Sun, Hongping
Liu, Chao
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
GD with ATD-induced hepatic injury or leukopenia occurs frequently in clinical practice.
The purpose of the present study was to observe the clinical effect of lithium carbonate on hyperthyroidism in patients with GD with hepatic injury or leukopenia.
Methods.
Fifty-one patients with GD with hepatic injury or leukopenia participated in the study.
All patients were treated with lithium carbonate, in addition to hepatoprotective drugs or drugs that increase white blood cell count.
Thyroid function, liver function, and white blood cells were measured.
Clinical outcomes were observed after a 1-year follow-up.
Results.
After treatment for 36 weeks, symptoms of hyperthyroidism and the level of thyroid hormones were improved and liver function, and white blood cells returned to a normal level.
Twelve patients (23.5%) obtained clinical remission, 6 patients (11.8%) relapsed after withdrawal, 25 patients (49.0%) received radioiodine therapy, and 8 patients (15.7%) underwent surgical procedures after lithium carbonate treatment.
Conclusion.
Lithium carbonate has effects on the treatment of mild-to-moderate hyperthyroidism caused by GD, and it is particularly suitable for patients with ATD-induced hepatic injury or leukopenia.
American Psychological Association (APA)
Zheng, Rendong& Liu, Kemian& Chen, Kun& Cao, Wen& Cao, Lin& Zhang, Huifeng…[et al.]. 2015. Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065784
Modern Language Association (MLA)
Zheng, Rendong…[et al.]. Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065784
American Medical Association (AMA)
Zheng, Rendong& Liu, Kemian& Chen, Kun& Cao, Wen& Cao, Lin& Zhang, Huifeng…[et al.]. Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065784