Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes
Joint Authors
Xu, Yan
Wang, Chun
Wang, Yijun
Wu, Junxia
Liu, Suyi
Zhu, Ying
Lv, Shurong
Lin, Ping
Wang, Xiaoke
Yu, Shali
Chen, Gang
Xiang, Quanyong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to evaluate the associations between chronic smoking and insulin resistance and β-cell function in Chinese men without diabetes.
A total of 1,568 participants were recruited by multistage sampling.
Using homeostatic model assessment (HOMA), geometric means of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) with 95% confidence interval (CI) were calculated by general linear model.
Odds ratios (ORs) with 95% CI were estimated to evaluate the associations between smoking status and insulin resistance and β-cell deficiency under a logistic regression model.
Current smokers had higher levels of 2 h glucose (6.66 versus 6.48 mmol/L) for oral glucose tolerance test and lower levels of fasting insulin (5.68 versus 6.03 mU/L) than never smokers.
The adjusted means for HOMA-β (%) were 54.86 in current smokers and 58.81 in never smokers (P=0.0257).
Current smoking was associated with β-cell deficiency (OR 1.29, 95% CI 1.01–1.64) compared to never smoking.
The β-cell function gradually decreased with increasing smoking intensity (Ptrend=0.0026), and the differences were statistically significant when the pack-year of smoking was 20 or above.
No association was observed between smoking status and HOMA-IR.
Our study suggested that chronic smoking may dose-dependently suppress insulin secretion in Chinese men.
American Psychological Association (APA)
Wang, Chun& Wang, Yijun& Wu, Junxia& Liu, Suyi& Zhu, Ying& Lv, Shurong…[et al.]. 2015. Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068014
Modern Language Association (MLA)
Wang, Chun…[et al.]. Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068014
American Medical Association (AMA)
Wang, Chun& Wang, Yijun& Wu, Junxia& Liu, Suyi& Zhu, Ying& Lv, Shurong…[et al.]. Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068014