The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies
Joint Authors
Martínez-Varea, Alicia
Serra, Vicente
Hervás-Marín, David
Martínez-Romero, Alicia
Bellver, José
Pellicer, Antonio
Perales-Marín, Alfredo
Pellicer, Begoña
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC; n=25), in vitro fertilization (IVF; n=25), and egg donation (ED; n=25) pregnancies.
The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transforming growth factor-beta (TGFβ), regulated upon activation normal T-cell expressed and secreted (RANTES), stromal cell-derived factor 1 alpha (SDF1α), and decidual granulocyte-macrophage colony-stimulating factor (GM-CSF) during the three trimesters of pregnancy during the three trimesters of pregnancy; secondly, to evaluate if the cytokine and chemokine pattern of ED pregnant women differs from that of those with autologous oocytes and, thirdly, to assess if women with preeclampsia show different cytokine and chemokine profile throughout pregnancy versus women with uneventful pregnancies.
Pregnant women in the three study groups displayed similar cytokine and chemokine pattern throughout pregnancy.
The levels of all quantified cytokines and chemokines, except RANTES, TNFα, IL8, TGFβ, and SDF1α, rose in the second trimester compared with the first, and these higher values remained in the third trimester.
ED pregnancies showed lower SDF1α levels in the third trimester compared with NC and IVF pregnancies.
Patients who developed preeclampsia displayed higher SDF1α plasma levels in the third trimester.
American Psychological Association (APA)
Martínez-Varea, Alicia& Pellicer, Begoña& Serra, Vicente& Hervás-Marín, David& Martínez-Romero, Alicia& Bellver, José…[et al.]. 2015. The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068361
Modern Language Association (MLA)
Martínez-Varea, Alicia…[et al.]. The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068361
American Medical Association (AMA)
Martínez-Varea, Alicia& Pellicer, Begoña& Serra, Vicente& Hervás-Marín, David& Martínez-Romero, Alicia& Bellver, José…[et al.]. The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068361