Modulation of Th1Th2 Immune Responses by Killed Propionibacterium acnes and Its Soluble Polysaccharide Fraction in a Type I Hypersensitivity Murine Model: Induction of Different Activation Status of Antigen-Presenting Cells
Joint Authors
Squaiella-Baptistão, Carla Cristina
Teixeira, Daniela
Mussalem, Juliana Sekeres
Ishimura, Mayari Eika
Longo-Maugéri, Ieda Maria
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Propionibacterium acnes (P.
acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions.
We previously demonstrated that heat-killed P.
acnes or its soluble polysaccharide (PS), extracted from the bacterium cell wall, suppressed or potentiated the Th2 response to ovalbumin (OVA) in an immediate hypersensitivity model, depending on the treatment protocol.
Herein, we investigated the mechanisms responsible for these effects, using the same model and focusing on the activation status of antigen-presenting cells (APCs).
We verified that higher numbers of APCs expressing costimulatory molecules and higher expression levels of these molecules are probably related to potentiation of the Th2 response to OVA induced by P.
acnes or PS, while higher expression of toll-like receptors (TLRs) seems to be related to Th2 suppression.
In vitro cytokines production in cocultures of dendritic cells and T lymphocytes indicated that P.
acnes and PS seem to perform their effects by acting directly on APCs.
Our data suggest that P.
acnes and PS directly act on APCs, modulating the expression of costimulatory molecules and TLRs, and these differently activated APCs drive distinct T helper patterns to OVA in our model.
American Psychological Association (APA)
Squaiella-Baptistão, Carla Cristina& Teixeira, Daniela& Mussalem, Juliana Sekeres& Ishimura, Mayari Eika& Longo-Maugéri, Ieda Maria. 2015. Modulation of Th1Th2 Immune Responses by Killed Propionibacterium acnes and Its Soluble Polysaccharide Fraction in a Type I Hypersensitivity Murine Model: Induction of Different Activation Status of Antigen-Presenting Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068363
Modern Language Association (MLA)
Squaiella-Baptistão, Carla Cristina…[et al.]. Modulation of Th1Th2 Immune Responses by Killed Propionibacterium acnes and Its Soluble Polysaccharide Fraction in a Type I Hypersensitivity Murine Model: Induction of Different Activation Status of Antigen-Presenting Cells. Journal of Immunology Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1068363
American Medical Association (AMA)
Squaiella-Baptistão, Carla Cristina& Teixeira, Daniela& Mussalem, Juliana Sekeres& Ishimura, Mayari Eika& Longo-Maugéri, Ieda Maria. Modulation of Th1Th2 Immune Responses by Killed Propionibacterium acnes and Its Soluble Polysaccharide Fraction in a Type I Hypersensitivity Murine Model: Induction of Different Activation Status of Antigen-Presenting Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068363