Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis
Joint Authors
Subbian, Selvakumar
Pandey, Ruchi
Soteropoulos, Patricia
Rodriguez, G. Marcela
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mycobacterium tuberculosis the causative agent of tuberculosis affects millions of people worldwide.
New tools for treatment and prevention of tuberculosis are urgently needed.
We previously showed that a ferritin (bfrB) mutant of M.
tuberculosis has altered iron homeostasis and increased sensitivity to antibiotics and to microbicidal effectors produced by activated macrophages.
Most importantly, M.
tuberculosis lacking BfrB is strongly attenuated in mice, especially, during the chronic phase of infection.
In this study, we examined whether immunization with a bfrB mutant could confer protection against subsequent infection with virulent M.
tuberculosis in a mouse model.
The results show that the protection elicited by immunization with the bfrB mutant is comparable to BCG vaccination with respect to reduction of bacterial burden.
However, significant distinctions in the disease pathology and host genome-wide lung transcriptome suggest improved containment of Mtb infection in animals vaccinated with the bfrB mutant, compared to BCG.
We found that downmodulation of inflammatory response and enhanced fibrosis, compared to BCG vaccination, is associated with the protective response elicited by the bfrB mutant.
American Psychological Association (APA)
Subbian, Selvakumar& Pandey, Ruchi& Soteropoulos, Patricia& Rodriguez, G. Marcela. 2015. Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068461
Modern Language Association (MLA)
Subbian, Selvakumar…[et al.]. Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068461
American Medical Association (AMA)
Subbian, Selvakumar& Pandey, Ruchi& Soteropoulos, Patricia& Rodriguez, G. Marcela. Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068461