Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery
Joint Authors
Nivsarkar, Megha S.
Buckley, Suzanne M. K.
Parker, Alan L.
Perocheau, Dany
McKay, Tristan R.
Rahim, Ahad A.
Howe, Steven J.
Waddington, Simon N.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined.
In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA.
The long-term tolerance of hFIX was robust in the face of immune challenge with hFIX protein and adjuvant but was eliminated by simultaneous administration of anti-CD25+ antibody.
Naive irradiated BALB/c mice which had received lymphocytes from donors immunised with hFIX developed anti-hFIX antibodies upon immune challenge.
Cotransplantation with CD4+CD25+ cells isolated from neonatally tolerized donors decreased the antibody response.
In contrast, cotransplantation with CD4+CD25− cells isolated from the same donors increased the antibody response.
These data provide evidence that immune tolerance following perinatal gene transfer is maintained by a CD4+CD25+ regulatory population.
American Psychological Association (APA)
Nivsarkar, Megha S.& Buckley, Suzanne M. K.& Parker, Alan L.& Perocheau, Dany& McKay, Tristan R.& Rahim, Ahad A.…[et al.]. 2015. Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068466
Modern Language Association (MLA)
Nivsarkar, Megha S.…[et al.]. Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068466
American Medical Association (AMA)
Nivsarkar, Megha S.& Buckley, Suzanne M. K.& Parker, Alan L.& Perocheau, Dany& McKay, Tristan R.& Rahim, Ahad A.…[et al.]. Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068466