Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease
Joint Authors
Mohammed-Ali, Zahraa
Cruz, Gaile L.
Dickhout, Jeffrey G.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The chronic inflammatory response is emerging as an important therapeutic target in progressive chronic kidney disease.
A key transcription factor in the induction of chronic inflammation is NF-κB.
Recent studies have demonstrated that sustained activation of the unfolded protein response (UPR) can initiate this NF-κB signaling phenomenon and thereby induce chronic kidney disease progression.
A key factor influencing chronic kidney disease progression is proteinuria and this condition has now been demonstrated to induce sustained UPR activation.
This review details the crosstalk between the UPR and NF-κB pathways as pertinent to chronic kidney disease.
We present potential tools to study this phenomenon as well as potential therapeutics that are emerging to regulate the UPR.
These therapeutics may prevent inflammation specifically induced in the kidney due to proteinuria-induced sustained UPR activation.
American Psychological Association (APA)
Mohammed-Ali, Zahraa& Cruz, Gaile L.& Dickhout, Jeffrey G.. 2015. Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068474
Modern Language Association (MLA)
Mohammed-Ali, Zahraa…[et al.]. Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068474
American Medical Association (AMA)
Mohammed-Ali, Zahraa& Cruz, Gaile L.& Dickhout, Jeffrey G.. Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068474