MGL Receptor and Immunity: When the Ligand Can Make the Difference
Joint Authors
Zizzari, Ilaria Grazia
Pierelli, Luca
Battisti, Federico
Rahimi, Hassan
Caponnetto, Salvatore
Napoletano, Chiara
Rughetti, Aurelia
Nuti, Marianna
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer.
In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) in the immune response against self-antigens, pathogens, and tumor associated antigens (TAA).
MGL is a CLR exclusively expressed by dendritic cells (DCs) and activated macrophages (MØs), able to recognize terminal GalNAc residues, including the sialylated and nonsialylated Tn antigens.
We discuss the effects on DC function induced throughout the engagement of MGL, highlighting the importance of the antigen structure in the modulation of immune response.
Indeed modifying Tn-density, the length, and steric structure of the Tn-antigens can result in generating immunogens that can efficiently bind to MGL, strongly activate DCs, mimic the effects of a danger signal, and achieve an efficient presentation in HLA classes I and II compartments.
American Psychological Association (APA)
Zizzari, Ilaria Grazia& Napoletano, Chiara& Battisti, Federico& Rahimi, Hassan& Caponnetto, Salvatore& Pierelli, Luca…[et al.]. 2015. MGL Receptor and Immunity: When the Ligand Can Make the Difference. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068480
Modern Language Association (MLA)
Zizzari, Ilaria Grazia…[et al.]. MGL Receptor and Immunity: When the Ligand Can Make the Difference. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068480
American Medical Association (AMA)
Zizzari, Ilaria Grazia& Napoletano, Chiara& Battisti, Federico& Rahimi, Hassan& Caponnetto, Salvatore& Pierelli, Luca…[et al.]. MGL Receptor and Immunity: When the Ligand Can Make the Difference. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068480