Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis
Joint Authors
Rogier, Rebecca
Koenders, Marije I.
Abdollahi-Roodsaz, Shahla
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In autoimmune diseases, a disturbance of the balance between T helper 17 (Th17) and regulatory T cells (Tregs) is often observed.
This disturbed balance is also the case in rheumatoid arthritis (RA).
Genetic predisposition to RA confers the presence of several polymorphisms mainly regulating activation of T lymphocytes.
However, the presence of susceptibility factors is neither necessary nor sufficient to explain the disease development, emphasizing the importance of environmental factors.
Multiple studies have shown that commensal gut microbiota is of great influence on immune homeostasis and can trigger the development of autoimmune diseases by favoring induction of Th17 cells over Tregs.
However the mechanism by which intestinal microbiota influences the Th cell balance is not completely understood.
Here we review the current evidence supporting the involvement of commensal intestinal microbiota in rheumatoid arthritis, along with a potential role of Toll-like receptors (TLRs) in modulating the relevant Th cell responses to trigger autoimmunity.
A better understanding of TLR triggering by intestinal microbiota and subsequent T cell activation might offer new perspectives for manipulating the T cell response in RA patients and may lead to the discovery of new therapeutic targets or even preventive measures.
American Psychological Association (APA)
Rogier, Rebecca& Koenders, Marije I.& Abdollahi-Roodsaz, Shahla. 2015. Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068509
Modern Language Association (MLA)
Rogier, Rebecca…[et al.]. Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068509
American Medical Association (AMA)
Rogier, Rebecca& Koenders, Marije I.& Abdollahi-Roodsaz, Shahla. Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068509