Immunodiagnostic Significance of Anti-RA33 Autoantibodies in Saudi Patients with Rheumatoid Arthritis
Author
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The primary objective of this study was to evaluate and compare the immunodiagnostic significance and utility of anti-RA33 with anti-CCP, RF, and CRP in Saudi patients with rheumatoid arthritis.
Methods.
This was a prospective controlled clinical study conducted at King Abdul Aziz University Tertiary Medical Centre.
The sera of 41 RA patients, 31 non-RA patients, and 29 healthy controls were collected.
Anti-RA33 and anti-CCP were measured using commercially available ELISA principle kits.
RF and CRP were measured using nephelometry.
Results.
Anti-RA33 antibodies had the lowest positive and negative predictive values and showed a sensitivity of 7.32% with 95.12% specificity.
Of the other three markers (including anti-CCP antibodies, CRP, and RF), only anti-CCP showed specificity of 90.46% with sensitivity of 63.41% compared to non-RA patients + healthy control.
There was a significant correlation with rheumatoid factor positivity with anti-CCP.
With respect to CRP, a notable correlation was seen only with anti-RA33.
Conclusion.
Compared to rheumatoid factor, anti-CCP antibodies, and C-reactive proteins, the anti-RA33 autoantibodies seem to be not representing as an important additional immunodiagnostic marker in Saudi patients with established RA.
RA33 may have more interest in early RA or less severe RA and other systemic connective tissue disorders.
American Psychological Association (APA)
al-Mughales, Jamil A.. 2015. Immunodiagnostic Significance of Anti-RA33 Autoantibodies in Saudi Patients with Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068531
Modern Language Association (MLA)
al-Mughales, Jamil A.. Immunodiagnostic Significance of Anti-RA33 Autoantibodies in Saudi Patients with Rheumatoid Arthritis. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068531
American Medical Association (AMA)
al-Mughales, Jamil A.. Immunodiagnostic Significance of Anti-RA33 Autoantibodies in Saudi Patients with Rheumatoid Arthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068531