The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi)
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Haemophilus influenzae is divided into typeable or nontypeable strains based on the presence or absence of a polysaccharide capsule.
The typeable strains (such as type b) are an important cause of systemic infection, whilst the nontypeable strains (designated as NTHi) are predominantly respiratory mucosal pathogens.
NTHi is present as part of the normal microbiome in the nasopharynx, from where it may spread down to the lower respiratory tract.
In this context it is no longer a commensal and becomes an important respiratory pathogen associated with a range of common conditions including bronchitis, bronchiectasis, pneumonia, and particularly chronic obstructive pulmonary disease.
NTHi induces a strong inflammatory response in the respiratory tract with activation of immune responses, which often fail to clear the bacteria from the lung.
This results in recurrent/persistent infection and chronic inflammation with consequent lung pathology.
This review will summarise the current literature about the lung immune response to nontypeable Haemophilus influenzae, a topic that has important implications for patient management.
American Psychological Association (APA)
King, Paul T.& Sharma, Roleen. 2015. The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi). Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068556
Modern Language Association (MLA)
King, Paul T.& Sharma, Roleen. The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi). Journal of Immunology Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1068556
American Medical Association (AMA)
King, Paul T.& Sharma, Roleen. The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi). Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068556