The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis
Joint Authors
Spinelli, F. R.
Conti, Fabrizio
Massaro, Laura
Truglia, Simona
Miranda, Francesca
Mastrangelo, Andrea
Colasanti, Tania
Pecani, Arbi
Sabatinelli, Danilo
Pendolino, Monica
Mancini, Riccardo
Barbati, C.
Alessandri, Cristiano
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The definition of posttranslational modification (PTM) encompasses a wide group of chemical reactions that allow modification and modulation of protein functions.
The regulation of PTMs is crucial for the activity and survival of the cells.
Dysregulation of PTMs has been observed in several pathological conditions, including rheumatoid arthritis (RA).
RA is a systemic autoimmune disease primarily targeting the joints.
The three PTMs mainly involved in this disease are glycosylation, citrullination, and carbamylation.
Glycosylation is essential for antigen processing and presentation and can modulate immunoglobulin activity.
Citrullination of self-antigens is strongly associated with RA, as demonstrated by the presence of antibodies directed to anti-citrullinated proteins in patients’ sera.
Carbamylation and its dysregulation have been recently associated with RA.
Aim of this review is to illustrate the most significant alterations of these PTMs in RA and to evaluate their possible involvement in the pathogenesis of the disease.
American Psychological Association (APA)
Mastrangelo, Andrea& Colasanti, Tania& Barbati, C.& Pecani, Arbi& Sabatinelli, Danilo& Pendolino, Monica…[et al.]. 2015. The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068560
Modern Language Association (MLA)
Mastrangelo, Andrea…[et al.]. The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068560
American Medical Association (AMA)
Mastrangelo, Andrea& Colasanti, Tania& Barbati, C.& Pecani, Arbi& Sabatinelli, Danilo& Pendolino, Monica…[et al.]. The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068560