Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study
Joint Authors
Valdovinos, Miguel A.
Aguilar-León, D.
Gamboa-Domínguez, A.
Martín-del-Campo, L. A.
Enríquez, A. B.
Coss-Adame, E.
Svarch, A. E.
Flores-Nájera, A.
Villa-Baños, A.
Ceballos, J. C.
Nuñez-Álvarez, Carlos
Torres-Villalobos, Gonzalo
Furuzawa-Carballeda, Janette
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Idiopathic achalasia is a disease of unknown etiology.
The loss of myenteric plexus associated with inflammatory infiltrates and autoantibodies support the hypothesis of an autoimmune mechanism.
Thirty-two patients diagnosed by high-resolution manometry with achalasia were included.
Twenty-six specimens from lower esophageal sphincter muscle were compared with 5 esophagectomy biopsies (control).
Immunohistochemical (biopsies) and flow cytometry (peripheral blood) analyses were performed.
Circulating anti-myenteric autoantibodies were evaluated by indirect immunofluorescence.
Herpes simplex virus-1 (HSV-1) infection was determined by in situ hybridization, RT-PCR, and immunohistochemistry.
Histopathological analysis showed capillaritis (51%), plexitis (23%), nerve hypertrophy (16%), venulitis (7%), and fibrosis (3%).
Achalasia tissue exhibited an increase in the expression of proteins involved in extracellular matrix turnover, apoptosis, proinflammatory and profibrogenic cytokines, and Tregs and Bregs versus controls ( P < 0.001 ).
Circulating Th22/Th17/Th2/Th1 percentage showed a significant increase versus healthy donors ( P < 0.01 ).
Type III achalasia patients exhibited the highest inflammatory response versus types I and II.
Prevalence of both anti-myenteric antibodies and HSV-1 infection in achalasia patients was 100% versus 0% in controls.
Our results suggest that achalasia is a disease with an important local and systemic inflammatory autoimmune component, associated with the presence of specific anti-myenteric autoantibodies, as well as HSV-1 infection.
American Psychological Association (APA)
Furuzawa-Carballeda, Janette& Aguilar-León, D.& Gamboa-Domínguez, A.& Valdovinos, Miguel A.& Nuñez-Álvarez, Carlos& Martín-del-Campo, L. A.…[et al.]. 2015. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068566
Modern Language Association (MLA)
Furuzawa-Carballeda, Janette…[et al.]. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1068566
American Medical Association (AMA)
Furuzawa-Carballeda, Janette& Aguilar-León, D.& Gamboa-Domínguez, A.& Valdovinos, Miguel A.& Nuñez-Álvarez, Carlos& Martín-del-Campo, L. A.…[et al.]. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068566