Regulation of Dendritic Cell Function in Inflammation
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system.
During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens.
Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC.
In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state.
We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermatitis.
Understanding the complex immunoregulatory role of distinct DC subsets in inflamed human skin will be a key element in developing novel strategies in anti-inflammatory therapy.
American Psychological Association (APA)
Said, André& Weindl, Günther. 2015. Regulation of Dendritic Cell Function in Inflammation. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068577
Modern Language Association (MLA)
Said, André& Weindl, Günther. Regulation of Dendritic Cell Function in Inflammation. Journal of Immunology Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068577
American Medical Association (AMA)
Said, André& Weindl, Günther. Regulation of Dendritic Cell Function in Inflammation. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068577