Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis
Joint Authors
Płoski, Rafał
Kisiel, Bartłomiej
Kruszewski, Robert
Juszkiewicz, Aleksandra
Raczkiewicz, Anna
Bachta, Artur
Tłustochowicz, Małgorzata
Staniszewska-Varga, Jadwiga
Kłos, Krzysztof
Duda, Krzysztof
Bogusławska-Walecka, Romana
Tłustochowicz, Witold
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
The risk of cardiovascular disease is increased in rheumatoid arthritis (RA).
A meta-analysis showed increased intima media thickness (IMT) in RA.
It has been shown that disease modifying antirheumatic drugs (DMARDs) may influence the progression of atherosclerosis.
However, it was suggested that biologics may be more efficient than other DMARDs (including methotrexate—MTX) in protecting against atherosclerosis.
Objectives.
The aim of this study was to assess the influence of different RA characteristics and treatment regimens on IMT and atherosclerotic plaques.
Patients and Methods.
317 RA patients and 111 controls were included in the study.
IMT was measured in carotid (CIMT) and femoral (FIMT) arteries.
Arteries were screened for the presence of plaques.
Results.
CIMT, FIMT, and prevalence of plaques were lower in patients treated with methotrexate (MTX) ≥ 20 mg/wk, cyclosporine (CsA), or biologics than in patients treated with lower doses of MTX and other disease modifying antirheumatic drugs.
No differences in IMT between patients treated with MTX ≥ 20 mg/wk, biologics, or CsA were found.
Conclusions.
We found a beneficial effect of MTX ≥ 20 mg/wk, biologics, and CsA on atherosclerosis.
We do not confirm a stronger influence of biologics on IMT compared with therapeutic doses of MTX.
American Psychological Association (APA)
Kisiel, Bartłomiej& Kruszewski, Robert& Juszkiewicz, Aleksandra& Raczkiewicz, Anna& Bachta, Artur& Tłustochowicz, Małgorzata…[et al.]. 2015. Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068587
Modern Language Association (MLA)
Kisiel, Bartłomiej…[et al.]. Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068587
American Medical Association (AMA)
Kisiel, Bartłomiej& Kruszewski, Robert& Juszkiewicz, Aleksandra& Raczkiewicz, Anna& Bachta, Artur& Tłustochowicz, Małgorzata…[et al.]. Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068587