Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice
Joint Authors
Weiss, Richard
Hattinger, E.
Scheiblhofer, S.
Roesler, E.
Thalhamer, T.
Thalhamer, J.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recently, mRNA vaccines have been introduced as a safety-optimized alternative to plasmid DNA-based vaccines for protection against allergy.
However, it remained unclear whether the short persistence of this vaccine type would limit memory responses and whether the protective immune response type would be maintained during recurrent exposure to allergen.
We tested the duration of protective memory responses in mice vaccinated with mRNA encoding the grass pollen allergen Phl p 5 by challenging them with recombinant allergen, 3.5, 6, and 9 months after vaccination.
In a second experiment, vaccinated mice were repeatedly challenged monthly with aerosolized allergen over a period of 7 months.
Antibody and cytokine responses as well as lung inflammation and airway hyperresponsiveness were assessed.
mRNA vaccination induced robust TH1 memory responses for at least 9 months.
Vaccination efficiently suppressed TH2 cytokines, IgE responses, and lung eosinophilia.
Protection was maintained after repeated exposure to aerosolized allergen and no TH1 associated pathology was observed.
Lung function remained improved compared to nonvaccinated controls.
Our data clearly indicate that mRNA vaccination against Phl p 5 induces robust, long-lived memory responses, which can be recalled by allergen exposure without side effects.
mRNA vaccines fulfill the requirements for safe prophylactic vaccination without the need for booster immunizations.
American Psychological Association (APA)
Hattinger, E.& Scheiblhofer, S.& Roesler, E.& Thalhamer, T.& Thalhamer, J.& Weiss, Richard. 2015. Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068600
Modern Language Association (MLA)
Hattinger, E.…[et al.]. Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068600
American Medical Association (AMA)
Hattinger, E.& Scheiblhofer, S.& Roesler, E.& Thalhamer, T.& Thalhamer, J.& Weiss, Richard. Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068600