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The Protective Role of HLA-DRB1 ∗ 13 in Autoimmune Diseases
Joint Authors
Almeida, Isabel
Selores Gomes Meirinhos, Maria Manuela
Bettencourt, Andreia
Carvalho, Cláudia
Leal, Bárbara
Brás, Sandra
Lopes, Dina
Martins da Silva, Ana
Santos, Ernestina
Torres, Tiago
Farinha, Fátima
Barbosa, Paulo
Correia, João
Costa, Paulo P.
da Silva, Berta Martins
Vasconcelos, Carlos
Marinho, António
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role.
We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls.
We confirmed previously established associations of HLA-DRB1 ∗ 15 (OR = 2.17) and HLA-DRB1 ∗ 03 (OR = 1.81) alleles with MS, HLA-DRB1 ∗ 03 with SLE (OR = 2.49), HLA-DRB1 ∗ 01 (OR = 1.79) and HLA-DRB1 ∗ 04 (OR = 2.81) with RA, HLA-DRB1 ∗ 07 with Ps + PsA (OR = 1.79), HLA-DRB1 ∗ 01 (OR = 2.28) and HLA-DRB1 ∗ 08 (OR = 3.01) with SSc, and HLA-DRB1 ∗ 03 with MG (OR = 2.98).
We further observed a consistent negative association of HLA-DRB1 ∗ 13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls).
HLA-DRB1 ∗ 13 frequency in the AIDs group was 20.0% (OR = 0.58).
Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1 ∗ 13, was underrepresented in all of the six diseases analysed.
This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease.
The protective effect of HLA-DRB1 ∗ 13 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection.
American Psychological Association (APA)
Bettencourt, Andreia& Carvalho, Cláudia& Leal, Bárbara& Brás, Sandra& Lopes, Dina& Martins da Silva, Ana…[et al.]. 2015. The Protective Role of HLA-DRB1 ∗ 13 in Autoimmune Diseases. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068649
Modern Language Association (MLA)
Bettencourt, Andreia…[et al.]. The Protective Role of HLA-DRB1 ∗ 13 in Autoimmune Diseases. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068649
American Medical Association (AMA)
Bettencourt, Andreia& Carvalho, Cláudia& Leal, Bárbara& Brás, Sandra& Lopes, Dina& Martins da Silva, Ana…[et al.]. The Protective Role of HLA-DRB1 ∗ 13 in Autoimmune Diseases. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068649