Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile
Joint Authors
Bottasso, Oscar Adelmo
Díaz, Ariana
Santucci, Natalia
Bongiovanni, Bettina
D’Attilio, Luciano
Massoni, Claudia
Lioi, Susana
Radcliffe, Stella
Dídoli, Griselda
Bay, María Luisa
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled.
Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology.
The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up.
Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation.
Twenty-four age- and sex-matched healthy controls (HCo) were also included.
Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo P<0.05), showing even higher values at T2 (versus T0 P<0.01) and T4 (versus T0 P<0.001).
While IL-6, IFN-γ, TGF-β (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9.
Tregs correlated positively with IFN-γ (R=0.868, P<0.05) at T2 and negatively at T4 (R=-0.795, P<0.05).
Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.
American Psychological Association (APA)
Díaz, Ariana& Santucci, Natalia& Bongiovanni, Bettina& D’Attilio, Luciano& Massoni, Claudia& Lioi, Susana…[et al.]. 2015. Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068664
Modern Language Association (MLA)
Díaz, Ariana…[et al.]. Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068664
American Medical Association (AMA)
Díaz, Ariana& Santucci, Natalia& Bongiovanni, Bettina& D’Attilio, Luciano& Massoni, Claudia& Lioi, Susana…[et al.]. Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068664