TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Retaining the delicate balance in cell signaling activity is a prerequisite for the maintenance of physiological tissue homeostasis.
Transforming growth factor-beta (TGFβ) signaling is an essential pathway that plays crucial roles during embryonic development as well as in adult tissues.
Aberrant TGFβ signaling activity regulates tumor progression in a cancer cell-autonomous or non-cell-autonomous fashion and these effects may be tumor suppressing or tumor promoting depending on the cellular context.
The fundamental role of this pathway in promoting cancer progression in multiple stages of the metastatic process, including epithelial-to-mesenchymal transition (EMT), is also becoming increasingly clear.
In this review, we discuss the latest advances in the effort to unravel the inherent complexity of TGFβ signaling and its role in cancer progression and metastasis.
These findings provide important insights into designing personalized therapeutic strategies against advanced cancers.
American Psychological Association (APA)
Papageorgis, Panagiotis. 2015. TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis. Journal of Oncology،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1069575
Modern Language Association (MLA)
Papageorgis, Panagiotis. TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis. Journal of Oncology No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1069575
American Medical Association (AMA)
Papageorgis, Panagiotis. TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1069575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069575