MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives
Joint Authors
Hasselbalch, Hans Carl
Bjørn, Mads Emil
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
In recent years the evidence is increasing that chronic inflammation may be an important driving force for clonal evolution and disease progression in the Philadelphia-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF).
Abnormal expression and activity of a number of proinflammatory cytokines are associated with MPNs, in particular MF, in which immune dysregulation is pronounced as evidenced by dysregulation of several immune and inflammation genes.
In addition, chronic inflammation has been suggested to contribute to the development of premature atherosclerosis and may drive the development of other cancers in MPNs, both nonhematologic and hematologic.
The MPN population has a substantial inflammation-mediated comorbidity burden.
This review describes the evidence for considering the MPNs as inflammatory diseases, A Human Inflammation Model of Cancer Development, and the role of cytokines in disease initiation and progression.
The consequences of this model are discussed, including the increased risk of second cancers and other inflammation-mediated diseases, emphasizing the urgent need for rethinking our therapeutic approach.
Early intervention with interferon-alpha2, which as monotherapy has been shown to be able to induce minimal residual disease, in combination with potent anti-inflammatory agents such as JAK-inhibitors is foreseen as the most promising new treatment modality in the years to come.
American Psychological Association (APA)
Hasselbalch, Hans Carl& Bjørn, Mads Emil. 2015. MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1070589
Modern Language Association (MLA)
Hasselbalch, Hans Carl& Bjørn, Mads Emil. MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1070589
American Medical Association (AMA)
Hasselbalch, Hans Carl& Bjørn, Mads Emil. MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1070589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070589